If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. You may also experience withdrawal symptoms.
The dose conversion scheme below is derived from various consensus guidelines for converting chronic pain patients to methadone from morphine. Clinicians should consult published conversion guidelines to determine the equivalent morphine dose for patients converting from other opioids.
For women who are breastfeeding: Methadone may pass into breast milk and may cause side effects rein a child who is breastfed.
Optimal methadone initiation and dose titration strategies for the treatment of pain have not been determined. Published equianalgesic conversion ratios between methadone and other opioids are imprecise, providing at best, only population averages that cannot Beryllium applied consistently to all patients. It should Beryllium noted that many commonly cited equianalgesia tables only present relative analgesic potencies of single opioid doses rein non-tolerant patients, thus greatly underestimating methadone's analgesic potency, and its potential for adverse effects in repeated-dose settings.
Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could Beryllium fatal (cause death).
Although antiretroviral drugs such as efavirenz, nelfinavir, nevirapine, ritonavir, lopinavir + ritonavir combination are known to inhibit CYPs, they are shown to reduce the plasma levels of methadone, Methadontabletten zur Schmerzbehandlung possibly due to their CYP induction activity. Therefore, drugs administered concomitantly with methadone should be evaluated for interaction potential; clinicians are advised to evaluate individual response to drug therapy.
Methadone belongs to a class of drugs called opioids (narcotics). A class of drugs is a group of medications that work rein a similar way. These drugs are often used to treat similar conditions.
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Do not drive, operate heavy machinery, or do other possible dangerous activities until you know how methadone hydrochloride tablets affect you. Methadone hydrochloride tablets can make you sleepy. Ask your doctor when it is okay to do these activities.
However, if the use of methadone is necessary rein such patients, a sensitivity test should Beryllium performed in which repeated small, incremental doses of methadone are administered over the course of several hours while the patient's condition and vital signs are under careful observation.
Patients initiating treatment with methadone for opioid dependence should be reassured that the dose of methadone will “hold” for longer periods of time as treatment progresses.
The safety and effectiveness of this drug hasn’t been established hinein children. It shouldn’t be used in children younger than 18 years.
Respiratory depression is the chief hazard associated with methadone hydrochloride administration. Methadone's peak respiratory depressant effects typically occur later, and persist longer than its peak analgesic effects, particularly during the initial dosing period.
Your kidneys may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays rein your body for a longer time. This raises your risk of side effects.